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So not only does excess weight lead to insulin resistance, which increases the risk of conditions like diabetes and heart disease, but inflammation as well, which can play a role in the uncontrolled growth of cells that lead to tumors, all of which can drastically lower our life expectancy

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This work not only highlights the potential off-target effect of semaglutide as an effective drug to treat metabolic osteoarthritis but also reveals a weight loss-independent repair mechanism that targets metabolic pathways and mediators essential to cartilage repair under osteoarthritis conditions, the study authors wrote